Uploaded by shang1818 on October 1, 2022 at 1:54 pm
The Landmark Study
Two Studies, a Lifetime of Proven Results
The Landmark Studies comprise the first multi-study, comprehensive look at the health impacts of long-term usage of a broad array of dietary supplements. The two studies, conducted in collaboration with the University of California Berkeley (2005) and, later, Tufts University (2015), compared long-term Shaklee adherents with a control group of US adults who took either no supplements or two or fewer supplements.
In the first study, members of the Shaklee group had healthier biomarkers and higher blood nutrient levels.* These differences generally persisted over the 10 years between the two studies. Additional findings from the 10-year follow-up study included a lower usage of medication in the Shaklee group, who were now an average age of 72.
The primary goal of these studies was to investigate the long-term health and nutritional status of individuals who regularly use multiple dietary supplements, particularly those manufactured by Shaklee Corporation, and compare them to non-supplement users and users of single multivitamins.
Key aspects and findings of the Landmark Health Studies include:
Focus on Long-Term Supplement Users: The studies specifically examined individuals who had been taking Shaklee supplements for extended periods, some for over 30 years.
Comparison Groups: Data from Shaklee supplement users were compared with data from the National Health and Nutrition Examination Survey (NHANES) for non-supplement users and those using a single multivitamin.
Biomarkers of Health: Researchers assessed various health biomarkers, including :
1. Nutrient Levels: Shaklee users generally had significantly higher levels of key nutrients like iron, folate, and vitamins A, C, E, D, and B12, and higher omega-3 index. This suggested effective absorption of nutrients from the supplements.
2. Heart Health: Shaklee users showed better markers of heart health, such as lower triglycerides, higher HDL (good) cholesterol, and lower LDL (bad) cholesterol.
3. Health and Inflammation: They also had lower levels of homocysteine (associated with cognitive decline) and C-reactive protein (CRP), a marker of inflammation.
4. Sugar Control and Weight Management: Later studies also indicated better glycemic control (lower glucose, insulin, and HbA1c) and healthier weight (lower BMI) among Shaklee users.
5. Risk of Chronic Diseases: The studies suggested a reduced risk of elevated blood pressure and self-reported diabetes in long-term Shaklee supplement users.
In essence, the Landmark Health Studies aim to provide scientific evidence regarding the impact of long-term, comprehensive dietary supplementation on various health indicators, with a specific focus on the efficacy of Shaklee's products.
Shaklee is the most clinically proven wellness company in the world
DR. FORREST C. SHAKLEE - FOUNDER AND INVENTOR OF THE FIRST MULTI-VITAMIN IN THE US
Our Mission
Bringing True Wellness to the World
Inspired by nature and proven by science, we are committed to developing the products and tools people need to live their healthiest lives.
This is the Shaklee Difference®
The Shaklee Difference®
Safe: Our products undergo a screening process that surpasses even the standards of the United States Pharmacopeia.
Proven: Our products are backed by 100+ patents and patents pending and 100+ published scientific papers.
Guaranteed: We stand behind our products with a 100% money-back guarantee—no questions asked.
The study showed that people who used Shaklee supplements had much healthier biomarkers for heart, brain, and cognitive health compared to non-supplement or non-Shaklee product single-supplement users.
Do Shaklee Supplements Work?
A Lifetime of Results Proves They Do
The Landmark Health Studies, the first multi-study to examine 30+ years of supplement use, show us that Shaklee users have better health outcomes than supplement non-users.**
The Results Speak for Themselves
Shaklee users showed significantly better health than sample groups.
How does this make you healthy?
Higher blood nutrient levels
Healthier biomarkers of health
Better health outcomes
Study Objectives
In this cross-sectional study, we examined the benefits of 20+ years of Shaklee supplement use. We compared Shaklee supplement users with non-supplement users and those who used a single multivitamin from other brands by assessing nutrient levels in their blood, and biomarkers reflecting various aspects of health.
This study followed up with people who participated in Landmark 1 to find out if the health benefits they originally experienced were still present 10 years later. It also explored new markers of health to further improve our understanding of the impact of long-term supplement use.
Study Details
To understand the relationship between supplementation and health, the Landmark Study was conducted in collaboration with researchers from the University of California, Berkeley.
Researchers looked at the health biomarkers and medication use in 156 people who had been taking Shaklee supplements for 30+ years (an additional 10 years of multiple supplement use) compared to 806 people who did not use any supplements.
After 10 years, Shaklee users still raise the bar for better health.
The benefits of Shaklee supplements persisted over time despite its users being on average 15 years older than the comparison group.
The Landmark Studies comprise the first multi-study, comprehensive look at the health impacts of long-term usage of a broad array of dietary supplements. The two studies, conducted in collaboration with the University of California Berkeley (2005) and, later, Tufts University (2015), compared long-term Shaklee adherents with a control group of US adults who took either no supplements or two or fewer supplements.
In the first study, members of the Shaklee group had healthier biomarkers and higher blood nutrient levels.* These differences generally persisted over the 10 years between the two studies. Additional findings from the 10-year follow-up study included a lower usage of medication in the Shaklee group, who were now an average age of 72.
The primary goal of these studies was to investigate the long-term health and nutritional status of individuals who regularly use multiple dietary supplements, particularly those manufactured by Shaklee Corporation, and compare them to non-supplement users and users of single multivitamins.
Key aspects and findings of the Landmark Health Studies include:
Focus on Long-Term Supplement Users: The studies specifically examined individuals who had been taking Shaklee supplements for extended periods, some for over 30 years.
Comparison Groups: Data from Shaklee supplement users were compared with data from the National Health and Nutrition Examination Survey (NHANES) for non-supplement users and those using a single multivitamin.
Biomarkers of Health: Researchers assessed various health biomarkers, including :
1. Nutrient Levels: Shaklee users generally had significantly higher levels of key nutrients like iron, folate, and vitamins A, C, E, D, and B12, and higher omega-3 index. This suggested effective absorption of nutrients from the supplements.
2. Heart Health: Shaklee users showed better markers of heart health, such as lower triglycerides, higher HDL (good) cholesterol, and lower LDL (bad) cholesterol.
3. Health and Inflammation: They also had lower levels of homocysteine (associated with cognitive decline) and C-reactive protein (CRP), a marker of inflammation.
4. Sugar Control and Weight Management: Later studies also indicated better glycemic control (lower glucose, insulin, and HbA1c) and healthier weight (lower BMI) among Shaklee users.
5. Risk of Chronic Diseases: The studies suggested a reduced risk of elevated blood pressure and self-reported diabetes in long-term Shaklee supplement users.
In essence, the Landmark Health Studies aim to provide scientific evidence regarding the impact of long-term, comprehensive dietary supplementation on various health indicators, with a specific focus on the efficacy of Shaklee’s products.
Shaklee is the most clinically proven wellness company in the world
DR. FORREST C. SHAKLEE – FOUNDER AND INVENTOR OF THE FIRST MULTI-VITAMIN IN THE US
Our Mission
Bringing True Wellness to the World
Inspired by nature and proven by science, we are committed to developing the products and tools people need to live their healthiest lives.
This is the Shaklee Difference®
The Shaklee Difference®
Safe: Our products undergo a screening process that surpasses even the standards of the United States Pharmacopeia.
Proven: Our products are backed by 100+ patents and patents pending and 100+ published scientific papers.
Guaranteed: We stand behind our products with a 100% money-back guarantee—no questions asked.
The study showed that people who used Shaklee supplements had much healthier biomarkers for heart, brain, and cognitive health compared to non-supplement or non-Shaklee product single-supplement users.
Do Shaklee Supplements Work?
A Lifetime of Results Proves They Do
The Landmark Health Studies, the first multi-study to examine 30+ years of supplement use, show us that Shaklee users have better health outcomes than supplement non-users.**
The Results Speak for Themselves
Shaklee users showed significantly better health than sample groups.
How does this make you healthy?
Higher blood nutrient levels
Healthier biomarkers of health
Better health outcomes
Study Objectives
In this cross-sectional study, we examined the benefits of 20+ years of Shaklee supplement use. We compared Shaklee supplement users with non-supplement users and those who used a single multivitamin from other brands by assessing nutrient levels in their blood, and biomarkers reflecting various aspects of health.
This study followed up with people who participated in Landmark 1 to find out if the health benefits they originally experienced were still present 10 years later. It also explored new markers of health to further improve our understanding of the impact of long-term supplement use.
Study Details
To understand the relationship between supplementation and health, the Landmark Study was conducted in collaboration with researchers from the University of California, Berkeley.
Researchers looked at the health biomarkers and medication use in 156 people who had been taking Shaklee supplements for 30+ years (an additional 10 years of multiple supplement use) compared to 806 people who did not use any supplements.
After 10 years, Shaklee users still raise the bar for better health.
The benefits of Shaklee supplements persisted over time despite its users being on average 15 years older than the comparison group.
We firmly believe that the internet should be available and accessible to anyone, and are committed to providing a website that is accessible to the widest possible audience,
regardless of circumstance and ability.
To fulfill this, we aim to adhere as strictly as possible to the World Wide Web Consortium’s (W3C) Web Content Accessibility Guidelines 2.1 (WCAG 2.1) at the AA level.
These guidelines explain how to make web content accessible to people with a wide array of disabilities. Complying with those guidelines helps us ensure that the website is accessible
to all people: blind people, people with motor impairments, visual impairment, cognitive disabilities, and more.
This website utilizes various technologies that are meant to make it as accessible as possible at all times. We utilize an accessibility interface that allows persons with specific
disabilities to adjust the website’s UI (user interface) and design it to their personal needs.
Additionally, the website utilizes an AI-based application that runs in the background and optimizes its accessibility level constantly. This application remediates the website’s HTML,
adapts Its functionality and behavior for screen-readers used by the blind users, and for keyboard functions used by individuals with motor impairments.
If you’ve found a malfunction or have ideas for improvement, we’ll be happy to hear from you. You can reach out to the website’s operators by using the following email
Screen-reader and keyboard navigation
Our website implements the ARIA attributes (Accessible Rich Internet Applications) technique, alongside various different behavioral changes, to ensure blind users visiting with
screen-readers are able to read, comprehend, and enjoy the website’s functions. As soon as a user with a screen-reader enters your site, they immediately receive
a prompt to enter the Screen-Reader Profile so they can browse and operate your site effectively. Here’s how our website covers some of the most important screen-reader requirements,
alongside console screenshots of code examples:
Screen-reader optimization: we run a background process that learns the website’s components from top to bottom, to ensure ongoing compliance even when updating the website.
In this process, we provide screen-readers with meaningful data using the ARIA set of attributes. For example, we provide accurate form labels;
descriptions for actionable icons (social media icons, search icons, cart icons, etc.); validation guidance for form inputs; element roles such as buttons, menus, modal dialogues (popups),
and others. Additionally, the background process scans all of the website’s images and provides an accurate and meaningful image-object-recognition-based description as an ALT (alternate text) tag
for images that are not described. It will also extract texts that are embedded within the image, using an OCR (optical character recognition) technology.
To turn on screen-reader adjustments at any time, users need only to press the Alt+1 keyboard combination. Screen-reader users also get automatic announcements to turn the Screen-reader mode on
as soon as they enter the website.
These adjustments are compatible with all popular screen readers, including JAWS and NVDA.
Keyboard navigation optimization: The background process also adjusts the website’s HTML, and adds various behaviors using JavaScript code to make the website operable by the keyboard. This includes the ability to navigate the website using the Tab and Shift+Tab keys, operate dropdowns with the arrow keys, close them with Esc, trigger buttons and links using the Enter key, navigate between radio and checkbox elements using the arrow keys, and fill them in with the Spacebar or Enter key.Additionally, keyboard users will find quick-navigation and content-skip menus, available at any time by clicking Alt+1, or as the first elements of the site while navigating with the keyboard. The background process also handles triggered popups by moving the keyboard focus towards them as soon as they appear, and not allow the focus drift outside of it.
Users can also use shortcuts such as “M” (menus), “H” (headings), “F” (forms), “B” (buttons), and “G” (graphics) to jump to specific elements.
Disability profiles supported in our website
Epilepsy Safe Mode: this profile enables people with epilepsy to use the website safely by eliminating the risk of seizures that result from flashing or blinking animations and risky color combinations.
Visually Impaired Mode: this mode adjusts the website for the convenience of users with visual impairments such as Degrading Eyesight, Tunnel Vision, Cataract, Glaucoma, and others.
Cognitive Disability Mode: this mode provides different assistive options to help users with cognitive impairments such as Dyslexia, Autism, CVA, and others, to focus on the essential elements of the website more easily.
ADHD Friendly Mode: this mode helps users with ADHD and Neurodevelopmental disorders to read, browse, and focus on the main website elements more easily while significantly reducing distractions.
Blindness Mode: this mode configures the website to be compatible with screen-readers such as JAWS, NVDA, VoiceOver, and TalkBack. A screen-reader is software for blind users that is installed on a computer and smartphone, and websites must be compatible with it.
Keyboard Navigation Profile (Motor-Impaired): this profile enables motor-impaired persons to operate the website using the keyboard Tab, Shift+Tab, and the Enter keys. Users can also use shortcuts such as “M” (menus), “H” (headings), “F” (forms), “B” (buttons), and “G” (graphics) to jump to specific elements.
Additional UI, design, and readability adjustments
Font adjustments – users, can increase and decrease its size, change its family (type), adjust the spacing, alignment, line height, and more.
Color adjustments – users can select various color contrast profiles such as light, dark, inverted, and monochrome. Additionally, users can swap color schemes of titles, texts, and backgrounds, with over 7 different coloring options.
Animations – epileptic users can stop all running animations with the click of a button. Animations controlled by the interface include videos, GIFs, and CSS flashing transitions.
Content highlighting – users can choose to emphasize important elements such as links and titles. They can also choose to highlight focused or hovered elements only.
Audio muting – users with hearing devices may experience headaches or other issues due to automatic audio playing. This option lets users mute the entire website instantly.
Cognitive disorders – we utilize a search engine that is linked to Wikipedia and Wiktionary, allowing people with cognitive disorders to decipher meanings of phrases, initials, slang, and others.
Additional functions – we provide users the option to change cursor color and size, use a printing mode, enable a virtual keyboard, and many other functions.
Browser and assistive technology compatibility
We aim to support the widest array of browsers and assistive technologies as possible, so our users can choose the best fitting tools for them, with as few limitations as possible. Therefore, we have worked very hard to be able to support all major systems that comprise over 95% of the user market share including Google Chrome, Mozilla Firefox, Apple Safari, Opera and Microsoft Edge, JAWS and NVDA (screen readers), both for Windows and for MAC users.
Notes, comments, and feedback
Despite our very best efforts to allow anybody to adjust the website to their needs, there may still be pages or sections that are not fully accessible, are in the process of becoming accessible, or are lacking an adequate technological solution to make them accessible. Still, we are continually improving our accessibility, adding, updating and improving its options and features, and developing and adopting new technologies. All this is meant to reach the optimal level of accessibility, following technological advancements. For any assistance, please reach out to
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